2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis) . 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production[1][2].

Product Specifications

CAS Number

[56-06-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-4-diamino-6-hydroxypyrimidine.html

Purity

99.97

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C1N=C(N)NC(N)=C1

Molecular Formula

C4H6N4O

Molecular Weight

126.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16 (2) :101-8.|[2]Kazuhisa Ikemoto, et al. 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH (4) -independent manner. Biochim Biophys Acta. Jul-Aug 2008;1780 (7-8) :960-5.|[3]T Kobayashi, et al. Gastrointestinal serotonin: depletion due to tetrahydrobiopterin deficiency induced by 2,4-diamino-6-hydroxypyrimidine administration. J Pharmacol Exp Ther. 1991 Feb;256 (2) :773-9.