What is the catalog number for A 83-01?

The catalog number for A 83-01 is HY-10432.

What sizes are available for A 83-01?

A 83-01 is available in the following size(s): 1 mg, 5 mg, 10 mg, 50 mg, 100 mg.

How many pack sizes does A 83-01 come in?

A 83-01 is available in 5 different pack sizes.

A 83-01 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures A 83-01?

A 83-01 is manufactured by QuantiMol.

What is the estimated delivery time for A 83-01?

Estimated delivery time for A 83-01 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for A 83-01?

The safety data sheet for A 83-01 is available here: http://file.medchemexpress.com/batch_PDF/HY-10432/A-83-01-SDS-MedChemExpress.pdf.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

A 83-01

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively[1].

Product Specifications

CAS Number

909910-43-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Organoid; TGF-β Receptor

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-83-01.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5

Molecular Formula

C25H19N5S

Molecular Weight

421.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96 (11) :791-800.|[2]Yamamura S, et al. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. Int J Cancer. 2012 Jan 1;130 (1) :20-8.|[3]Taniguchi Y, et al. Enhanced antitumor efficacy of folate-linked liposomal Adriamycin with TGF-β type I receptor inhibitor. Cancer Sci. 2010 Oct;101 (10) :2207-13.