Lin28-let-7 antagonist 1
Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells[1].
Product Specifications
CAS Number
[108825-65-6]
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lin28-let-7-antagonist-1.html
Purity
99.43
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(C(C)=O)C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1
Molecular Formula
C15H15N5O
Molecular Weight
281.32
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Roos M, et al. A Small-Molecule Inhibitor of Lin28. ACS Chem Biol. 2016 Oct 21;11 (10) :2773-2781.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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