Phlotoxin-1
Product Specifications
UNSPSC Description
Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel[1][2].
Target Antigen
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/phlotoxin-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3C)=O)=O)=O)=O)NC4=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CC9=CC=C(C=C9)O)C(N%10[C@@H](CCC%10)C(N[C@H]%11CC%12=CNC%13=CC=CC=C%12%13)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(O)=O)C(N%14[C@@H](CCC%14)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC%16=CC=CC=C%16)C(O)=O)=O)=O)=O)=O)=O)NC%11=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Weight
4058.64
References & Citations
[1]Gonçalves TC, et al. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel). 2019 Aug 22;11(9):484.|[2]Nicolas S, et al. Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5160/Phlotoxin-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5160/
Clinical Information
No Development Reported
Curated Selection
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