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Depatuxizumab mafodotin

Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate (ADC) . Depatuxizumab mafodotin specifically targets the epidermal growth factor receptor (EGFR) . Depatuxizumab mafodotin can be used in the study of glioma, head and neck squamous cell carcinoma, non-small cell lung cancer, epidermoid carcinoma of the skin, and squamous cell carcinoma of the tongue[1][2][3][4][5].

Product Specifications

CAS Number

1585973-65-4

Product Name Alternative

ABT-414

UNSPSC

12352211

Target

Antibody-Drug Conjugates (ADCs) ; EGFR

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/depatuxizumab-mafodotin.html

Purity

99.73

Solubility

10 mM in DMSO

Smiles

[Depatuxizumabmafodotin]

References & Citations

[1]Goss G D, et al. Efficacy and safety results of depatuxizumab mafodotin (ABT‐414) in patients with advanced solid tumors likely to overexpress epidermal growth factor receptor[J]. Cancer, 2018, 124 (10) : 2174-2183.|[2]Padovan M, et al. Depatuxizumab Mafodotin (Depatux-M) Plus Temozolomide in Recurrent Glioblastoma Patients: Real-World Experience from a Multicenter Study of Italian Association of Neuro-Oncology (AINO) . Cancers (Basel) . 2021 Jun 3;13 (11) :2773.|[3]von Achenbach C, et al. Depatuxizumab Mafodotin (ABT-414) -induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation. Mol Cancer Ther. 2020 Jun;19 (6) :1328-1339.|[4]Mani L, et al. Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer. Carcinogenesis. 2024 Jul 8;45 (7) :520-526.|[5]Phillips AC, et al. ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. Mol Cancer Ther. 2016 Apr;15 (4) :661-9.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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