(R) -OP-1074

(R) -OP-1074 is an isomer of OP-1074 (HY-125263) and can serve as a control compound in experiments. OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2) -stimulated transcription with IC50 values of 1.6 and 3.2 nM, respectively.

Product Specifications

CAS Number

[1443752-77-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-op-1074.html

Purity

98.24

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)[C@@H](C4=CC=C(OCCN5C[C@H](C)CC5)C=C4)OC2=C1

Molecular Formula

C29H31NO4

Molecular Weight

457.56

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fanning SW, et al. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.Nat Commun. 2018 Jun 18;9 (1) :2368.