Tricin

Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 [1][2][3][1][2][3][4][5].

Product Specifications

CAS Number

[520-32-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CMV

Type

Natural Products

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tricin.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(C2=CC(OC)=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C17H14O7

Molecular Weight

330.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Itoh A, et al. Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus. Microbiol Immunol. 2018 May;62 (5) :341-347.|[2]Sadanari H, et al. The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. FEBS Open Bio. 2018 Feb 20;8 (4) :646-654.|[3]Chung DJ, et al. Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7. J Agric Food Chem. 2018 Jul 5;66 (26) :6708-6716.|[4]Yazawa K, et al. Anti-influenza virus activity of tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone. Antivir Chem Chemother. 2011 Aug 23;22 (1) :1-11.|[5]Oyama T, et al. Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. Cancer Prev Res (Phila) . 2009 Dec;2 (12) :1031-8.