DGK-IN-1

DGK-IN-1 is a DGK inhibitor (DGKa/DGKz IC50: 0.65/0.25 μM) . DGK-IN-1 is a T cell activator that can be used in cancer and viral infection research[1].

Product Specifications

CAS Number

[2407892-34-4]

UNSPSC

12352005

Target

DGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dgk-in-1.html

Purity

98.67

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=NC2=C(N(C)C(C=C2N3[C@@H](C)CN(C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)[C@H](C)C3)=O)C=C1

Molecular Formula

C29H27Cl2N5O

Molecular Weight

532.46

References & Citations

[1]Velaparthi U, et al. Preparation of substituted naphthyridinone compounds useful as T cell activators. WO2020006018A1. World Intellectual Property Organization. A1 2020-01-02.