Neotame

Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells[1][2][3].

Product Specifications

CAS Number

[165450-17-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Drug Derivative; Taste Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/neotame.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC([C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NCCC(C)(C)C)=O)=O

Molecular Formula

C20H30N2O5

Molecular Weight

378.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Liang Chi, et al. Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. Molecules. 2018 Feb 9;23 (2) :367.|[2]Anuradha Kumari, et al. Stability of Aspartame and Neotame in Pasteurized and In-Bottle Sterilized Flavoured Milk. Food Chem. 2016 Apr 1;196:533-8.|[3]Shil A, et al. The artificial sweetener neotame negatively regulates the intestinal epithelium directly through T1R3-signaling and indirectly through pathogenic changes to model gut bacteria. Front Nutr. 2024 Apr 24;11:1366409.