Pitstop 2

Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2].

Product Specifications

CAS Number

[1419320-73-2]

Product Name Alternative

SPDP Crosslinker; Py-ds-Prp-OSu

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pitstop-2.html

Purity

98.42

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=C2C=CC=CC2=CC=C1)(NC(S/C3=C\C4=CC=C(Br)C=C4)=NC3=O)=O

Molecular Formula

C20H13BrN2O3S2

Molecular Weight

473.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9 (1) : 12636.|[2]Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.