2′-O-Methyl-8-methyl guanosine

2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions[1]. m8Gm-contained oligonucleotides stabilize the Z-DNA under low salt conditions[2].

Product Specifications

CAS Number

[2306782-64-7]

Product Name Alternative

M8Gm

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Oligonucleotides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-o-methyl-8-methyl-guanosine.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](OC)[C@H](N2C(NC(N)=NC3=O)=C3N=C2C)O[C@@H]1CO

Molecular Formula

C12H17N5O5

Molecular Weight

311.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Balasubramaniyam T, Ishizuka T, Xu Y. Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine. Bioorg Med Chem. 2019;27 (2) :364-369.|[2]Balasubramaniyam T, Ishizuka T, Xiao CD, Bao HL, Xu Y. 2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. Molecules. 2018;23 (10) :2572.