(R) -Nepicastat (hydrochloride)
(R) -Nepicastat hydrochloride is the isomer of Nepicastat. Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB)[2][3].
Product Specifications
CAS Number
195881-94-8
Product Name Alternative
(R) -SYN117 (hydrochloride) ; (R) -RS-25560-197 (hydrochloride) ; RS-25560-198 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dopamine β-hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/r-nepicastat-hydrochloride.html
Smiles
S=C1NC=C(CN)N1[C@H]2CC3=C(C(F)=CC(F)=C3)CC2.Cl
Molecular Formula
C14H16ClF2N3S
Molecular Weight
331.81
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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