TRK-IN-28

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRKWT, TRKG595R and TRKG667C, respectively. TRK-IN-2 shows antiproliferative activity with IC50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKAWT, Ba/F3-ETV6-TRKBWT, Ba/F3-LMNA-TRKG595R and Ba/F3-LMNA-TRKAG667C, respectively[1].

Product Specifications

CAS Number

[2991504-43-7]

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trk-in-28.html

Solubility

10 mM in DMSO

Smiles

FC1=CC(CC2=CC3=C(NN=C3NC4=C5C=CC(N6CCN(CC6)C)=CC5=NC=N4)C=C2)=CC(F)=C1

Molecular Formula

C27H25F2N7

Molecular Weight

485.53

References & Citations

[1]Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608.