(rac) -Exatecan Intermediate 1

(rac) -Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487) . Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer[1][2].

Product Specifications

CAS Number

[102978-40-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10_4H_-trione.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O

Molecular Formula

C13H13NO5

Molecular Weight

263.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13 (4) :950-973.|[2]Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31.