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Anti-GluA1-GluR1 Antibody

Mouse Monoclonal Antibody specific to GluA1/GluR1

Product Specifications

Product Name Alternative

GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1

Gene Name

Gria1

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=Gria1">Gria1</a>

UniProt

P19490

Cellular Locus

Cell membrane, Endoplasmic reticulum membrane, Cell junction, synapse, postsynaptic cell membrane, Cell junction, synapse, postsynaptic density membrane, Cell projection, dendrite, Cell projection, dendritic spine, Early endosome membrane, Recycling endosome membrane, Cell junction, synapse, presynapse, Cell junction, synapse

Host

Mouse

Reactivity

Mouse, Rat

Immunogen

Fusion protein corresponding to aa 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (accession no. P19490).

Target Antigen

Glutamate receptor 1

Target

GluA1-GluR1

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, ICC/IF

Field of Research

Neuroscience

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {PubMed:16793768, PubMed:19265014}.

Additionnal Information

Immunoblotting: use at 1ug/mL. A band of ~100kDa is detected. <br><br>Positive control: Rat brain lysate. <br><br>These are recommended concentrations. User should determine optimal concentrations for their application.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/56547.pdf

Specificity

This antibody recognizes mouse and rat GluA1/GluR1. It does not cross-react with GluR2.

Formulation

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

Buffer pH

pH 7.4

Target Background

Regulation of alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionic acid receptors (AMPARs) plays a key role in altering excitatory synaptic transmission in the CNS. Interestingly, the regulatory mechanisms differ between distinct subunits of AMPAR, which range from glutamate receptor 1 (GluR1) to GluR4 (also referred to as GluA1–4). For example, subunits with a long intracellular carboxy terminus (i.e., GluR1, GluR2L, and GluR4) are involved in activity- dependent synaptic targeting of AMPAR, whereas those with a shorter carboxy terminus (i.e., GluR2, GluR3, and GluR4s) seem to maintain basal synaptic transmission. GluR1 has several phosphorylation sites on the intracellular carboxy terminus. Many of these sites have been demonstrated to play a role in synaptic AMPAR regulation and synaptic plasticity.

CAS Number

9007-83-4

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