AK-1690
AK-1690 is a potent and selective STAT6 PROTAC degrader. AK-1690 reduces the levels of STAT6 protein in cells (DC50=1 nM) and depletes STAT6 protein in mouse tissues. AK-1690 can be used for the research of cancer. (Pink: ligand for target protein STAT6 (HY-169182) ; Black: linker (HY-W459522) ; Blue: ligand for E3 ligase (HY-131318) [1].
Product Specifications
CAS Number
[2984505-88-4]
UNSPSC
12352005
Target
PROTACs; STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ak-1690.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C51H56F2N5O11PS
Molecular Weight
1016.05
References & Citations
[1]Kaneshige A, et, al. Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader. J Med Chem. 2024 Sep 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Hot
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; STAT6
Available Sizes
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