AChE-IN-59
AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD) [1].
Product Specifications
CAS Number
2957916-86-6
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-59.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2C=C(C(OC2=C1)=O)NC(C3CCN(CC3)CC4=CC(OC)=CC(OC)=C4)=O
Molecular Formula
C25H28N2O6
Molecular Weight
452.50
References & Citations
[1]Zhai J, et al. Design, synthesis, and evaluation of dual-target inhibitors for the treatment of Alzheimer's disease. Arch Pharm (Weinheim) . 2024 Feb 8:e2300693.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Frequently Asked Questions
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