ALK2-IN-2
Product Specifications
UNSPSC Description
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3[1].
Target Antigen
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk2-in-2.html
Purity
99.56
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(N1CCCC1)C(C=C2)=CC=C2C(C=N3)=CN4C3=C(C5=CC=C(S(=O)(N)=O)C6=C5C=CC=C6)C=N4
Molecular Weight
497.61
References & Citations
[1]Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3356-3362.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112815/ALK2-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112815/ALK2-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2254409-25-9
Available Sizes
Curated Selection
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