ALK2-IN-2

ALK2-IN-2 is an orally active and selective inhibitor of ALK2 (ACVR1), with an IC50 value of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 can inhibit oxidative stress and protect endothelial cells[1][2].

Product Specifications

CAS Number

[2254409-25-9]

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alk2-in-2.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(N1CCCC1)C(C=C2)=CC=C2C(C=N3)=CN4C3=C(C5=CC=C(S(=O)(N)=O)C6=C5C=CC=C6)C=N4

Molecular Formula

C28H27N5O2S

Molecular Weight

497.61

References & Citations

[1]Jiang JK, et al. Discovery of 3- (4-sulfamoylnaphthyl) pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3356-3362.|[2]Cao C, et al. Circulating exosomes repair endothelial cell damage by delivering miR-193a-5p. J Cell Mol Med. 2021 Feb;25 (4) :2176-2189.