AG 555

AG 555 (Tyrphostin AG 555), a potent antiretroviral agent, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation[1][2].

Product Specifications

CAS Number

[133550-34-2]

Product Name Alternative

Tyrphostin AG 555

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

EGFR; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AG_555.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

Molecular Formula

C19H18N2O3

Molecular Weight

322.36

Precautions

H315, H319, H335

References & Citations

[1]Seri E Aflalo, et al. Tyrphostin AG-555 inhibits early and late stages of Moloney murine leukemia virus replication cycle. International Journal of Oncology. 1997.|[2]Nir Osherov, et al. Tyrphostin AG494 blocks Cdk2 activation Nir Osherov. FEBS Letters 410 (1997) 187-190.|[3]Sabine Baars, et al. Tyrphostin AG 555 Inhibits Bovine Papillomavirus Transcription by Changing the Ratio between E2 Transactivator/Repressor Function. Vol. 278, No. 39, Issue of September 26, pp. 37306–37313, 2003.