Biotin-VAD-FMK

Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Product Specifications

CAS Number

[1135688-15-1]

UNSPSC

12352200

Target

Caspase

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Biotin-VAD-FMK.html

Purity

98.0

Solubility

DMSO : ≥ 27.3 mg/mL

Smiles

COC(C[C@@H](C(CF)=O)NC([C@H](C)NC([C@H](C(C)C)NC(CCCCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)=O)=O)=O)=O

Molecular Formula

C30H49FN6O8S

Molecular Weight

672.81

References & Citations

[1]Li J, et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem. 1999 Jun 11;274 (24) :17325-33.|[2]Samraj AK, et al. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membranedepolarization. Mol Biol Cell. 2007 Jan;18 (1) :84-93.