Exatecan Intermediate 5
Exatecan Intermediate 5 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).
Product Specifications
CAS Number
143655-70-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-5.html
Purity
99.98
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C
Molecular Formula
C15H17FN2O3
Molecular Weight
292.31
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
Frequently Asked Questions
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