Exatecan Intermediate 5

Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs) .

Product Specifications

CAS Number

[143655-70-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/exatecan-intermediate-5.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C

Molecular Formula

C15H17FN2O3

Molecular Weight

292.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.