PPARγ agonist 16
PPARγ agonist 16 (Compound 4G) is the agonist for PPARγ, that competitively binds to LBD domain of PPARγ with IC50 of 1790 nM. PPARγ agonist 16 inhibits the ear swelling in mouse model, and exhibits anti-hyperglycemic in Streptozotocin -induced mouse diabetes mellitus model[1].
Product Specifications
CAS Number
2218046-01-4
UNSPSC
12352101
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pparγ-agonist-16.html
Smiles
BrC1=CC=C(C(CN2C(/C(SC2=O)=C/C3=C(OC)C=CC=C3)=O)=O)C=C1
Molecular Formula
C19H14BrNO4S
Molecular Weight
432.29
References & Citations
[1]Sun J, et al., Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorg Chem. 2021 Nov;116:105342.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
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