N-Butanoyl-DL-homoserine lactone

N-Butanoyl-DL-homoserine lactone ((Rac) -C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[1][2].

Product Specifications

CAS Number

[98426-48-3]

Product Name Alternative

(Rac) -C4-HSL

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-butanoyl-dl-homoserine-lactone.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCC(NC1C(OCC1)=O)=O

Molecular Formula

C8H13NO3

Molecular Weight

171.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14 (2) :e0212041.|[2]Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1