LY2794193

LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM, EC50=0.47 nM; hmGlu2 Ki=412 nM, EC50=47.5 nM) [1].

Product Specifications

CAS Number

[2173037-97-1]

Product Name Alternative

2'-3'-cyclic GMP-AMP,2'-3'-cyclic GMP-AMP (sodium)

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LY2794193.html

Purity

99.65

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; adjust pH to 14 with NaOH)

Smiles

O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])[C@@H](NC(C3=CC=CC(OC)=C3)=O)C1)O

Molecular Formula

C16H18N2O6

Molecular Weight

334.32

References & Citations

[1]Monn JA, et al. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S) -2-Amino-4-[ (3-methoxybenzoyl) amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61 (6) :2303-2328.