What is the catalog number for TPCK?

The catalog number for TPCK is HY-124379.

What sizes are available for TPCK?

TPCK is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg.

How many pack sizes does TPCK come in?

TPCK is available in 4 different pack sizes.

TPCK is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TPCK?

TPCK is manufactured by QuantiMol.

What is the estimated delivery time for TPCK?

Estimated delivery time for TPCK is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TPCK?

The safety data sheet for TPCK is available here: http://file.medchemexpress.com/batch_PDF/HY-124379/TPCK-SDS-MedChemExpress.pdf.

TPCK

TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats[1][2][3][4][5].

Product Specifications

CAS Number

402-71-1

Product Name Alternative

L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK

UNSPSC

12352005

Hazard Statement

H315, H318, H335

Target

Apoptosis; HPV; PDK-1; Ser/Thr Protease

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tpck.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)S(N[C@@H](CC2=CC=CC=C2)C(CCl)=O)(=O)=O

Molecular Formula

C17H18ClNO3S

Molecular Weight

351.85

Precautions

H315, H318, H335

References & Citations

[1]H Stöppler, et al. The serine protease inhibitors TLCK and TPCK react with the RB-binding core of HPV-18 E7 protein and abolish its RB-binding capability. Virology. 1996 Mar 15;217 (2) :542-53.|[2]Patrícia de A Machado, et al. Effects of a Serine Protease Inhibitor N- p-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on Leishmania amazonensis and Leishmania infantum. Pharmaceutics.2022 Jun 29;14 (7) :1373.|[3]H Stöppler, et al. The serine protease inhibitors TLCK and TPCK react with the RB-binding core of HPV-18 E7 protein and abolish its RB-binding capability. Virology. 1996 Mar 15;217 (2) :542-53.|[4]M H LeBlanc, et al. N-tosyl-L-phenylalanyl-chloromethylketone reduces hypoxic-ischemic brain injury in rat pups. Eur J Pharmacol. 2000 Mar 3;390 (3) :249-56|[5]K Watanabe, et al. Vascular permeability changes by proteinase inhibitors in carrageenin-induced inflammation in rats. Agents Actions. 1986 Mar;17 (5-6) :472-7.