Forsythoside I

Forsythoside I is an orally active caffeoyl phenylethanoid glycoside (CPG) that can be isolated from Forsythia suspense (Thunb.) Vahl. Forsythoside I has anti-inflammatory activity and can exert a protective effect in a mouse model of acute lung injury[1][2].

Product Specifications

CAS Number

[1177581-50-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Arrestin; Caspase; Interleukin Related; NOD-like Receptor (NLR) ; SOD

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/forsythoside-i.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H](OC(/C=C/C1=CC=C(O)C(O)=C1)=O)[C@@H]([C@@H](CO[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)O3)O)[C@@H]3OCCC4=CC=C(O)C(O)=C4

Molecular Formula

C29H36O15

Molecular Weight

624.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang FN, et al. New phenylethanoid glycosides from the fruits of forsythia suspense (thunb.) vahl. Molecules. 2009 Mar 25;14 (3) :1324-31.|[2]Liang H, et al. Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome. Mol Immunol. 2021 Jun;134:192-201.