PGD2-IN-1
PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d) ; has an IC50 of 0.3 nM.
Product Specifications
CAS Number
885066-67-1
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PGD2-IN-1.html
Concentration
10mM
Purity
98.24
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)C(C)(C)C1=CC=CC(C2=NC(OC)=NC(NCCC3=CC=C(Cl)C=C3Cl)=C2)=C1
Molecular Formula
C23H23Cl2N3O3
Molecular Weight
460.35
Precautions
H315, H319, H335
References & Citations
[1]Lim, Sungtaek, et al. 2, 6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS. WO2006044732A2.|[2]Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21 (1) :66-75.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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