DHFR-IN-22

DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections[1].

Product Specifications

CAS Number

[2941327-87-1]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-22.html

Smiles

O=C(O)CCC1=C(OCCCOC2=C(N)N=C(N)N=C2C3CCCCC3)C=CC=C1

Molecular Formula

C22H30N4O4

Molecular Weight

414.50

References & Citations

[1]Andrade Meirelles M, et al. Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens. J Med Chem. 2024 Nov 14;67 (21) :19143-19164.