Ent- (+) -Verticilide

Ent- (+) -verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent- (+) -verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent- (+) -verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1].

Product Specifications

CAS Number

[2056011-05-1]

UNSPSC

12352005

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ent-plus-verticilide.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H]1C(N([C@@H](C(O[C@H](C(N([C@@H](C(O[C@H](C(N([C@@H](C(O[C@H](C(N([C@@H](C(O1)=O)C)C)=O)CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O

Molecular Formula

C44H76N4O12

Molecular Weight

853.09

References & Citations

[1]Suzanne M Batiste, et al. Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proc Natl Acad Sci U S A. 2019 Mar 12;116 (11) :4810-4815.