COX-1/2-IN-9
Product Specifications
UNSPSC Description
COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states[1].
Target Antigen
Bacterial; COX
Type
Reference compound
Related Pathways
Anti-infection;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-1-2-in-9.html
Smiles
IC1=CC2=C(N=C(SCC(NC3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)N(C4=CC=C(S(=O)(NCC(NC5=CC=C([N+]([O-])=O)C=C5[N+]([O-])=O)=O)=O)C=C4)C2=O)C=C1
Molecular Weight
905.57
References & Citations
[1]Soliman A M, et al. Novel quinazoline sulfonamide-based scaffolds modulate methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in immunodeficient irradiated model: Regulatory role of TGF-β[J]. Bioorganic Chemistry, 2024: 107559.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162761/COX-1-2-IN-9-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162761/
Clinical Information
No Development Reported
Curated Selection
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