Coptisine (Sulfate)

Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM[1].

Product Specifications

CAS Number

[1198398-71-8]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/coptisine-sulfate.html

Purity

99.37

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(O)([O-])=O.C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6

Molecular Formula

C19H15NO8S

Molecular Weight

417.39

References & Citations

[1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43 (1) :291-302.