L-Asparagine (Standard)
L-Asparagine (Standard) is the analytical standard of L-Asparagine. This product is intended for research and analytical applications. L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5].
Product Specifications
CAS Number
70-47-3
Product Name Alternative
(-) -Asparagine (Standard) ; Asn (Standard) ; Asparamide (Standard)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-asparagine-standard.html
Purity
99.91
Smiles
N[C@H](C(O)=O)CC(N)=O
Molecular Formula
C4H8N2O3
Molecular Weight
132.12
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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