PJ34
Product Specifications
UNSPSC Description
PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pj34.html
Smiles
O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C
Molecular Weight
295.34
References & Citations
[1]Iwashita A, et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[2]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149(1):23-30.Antioxidants (Basel). 2024 Apr 26, 13(5), 525.|Antioxidants (Basel). 2024 Apr 26;13(5):525.|Apoptosis. 2021 Sep 28.|Biochim Biophys Acta Mol Basis Dis. 2024 Apr 22;1870(5):167190.|Bioorg Chem. 2024 Apr 29:147:107412.|bioRxiv. 2023 Oct 4.|bioRxiv. 2024 September 19.|Cancer Lett. 2021 Jul 3;S0304-3835(21)00325-6.|Free Radic Biol Med. 2021 Dec 16;S0891-5849(21)01112-6.|J Invest Dermatol. 2024 May 30:S0022-202X(24)00384-1.|J Virol. 2021 May 26;JVI0076021.|Mol Med Rep. 2024 Jun;29(6):102.|Nat Aging. 2024 May 9.|Norges teknisk-naturvitenskapelige universitet. 2024.|Nottingham Trent University. 2023 Sep 12.|Part Fibre Toxicol. 2020 Jun 8;17(1):23. |Patent. US20180263995A1.|Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2213857120.|Regen Ther. 2023 Dec, 24, 592-601.|Research Square Print. 2022.|Sci Signal. 2023 Jan 17;16(768):eabh1083.|Acta Biomater. 2022 May 25;S1742-7061(22)00310-5.|Anim Cells Syst. 03 Aug 2022.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Sci Rep. 2017 May 23;7(1):2268.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13688A/PJ34-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13688A/PJ34-SDS-MedChemExpress.pdf
CAS Number
344458-19-1
Available Sizes
Curated Selection
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