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EPZ0025654

EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC50 of 3 nM[1].

Product Specifications

CAS Number

1888328-89-9

Product Name Alternative

GSK3536023

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/epz0025654.html

Smiles

O[C@H](CNC)COC1=CC=C(Cl)C(C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5=NC(N6CCC6)=NC=C5C4)=N2)=C1

Molecular Formula

C29H33ClN8O3

Molecular Weight

577.08

References & Citations

[1]Li ASM, et al., Chemical probes for protein arginine methyltransferases. Methods. 2020 Mar 15;175:30-43.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT6

Frequently Asked Questions

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