EPZ0025654
EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC50 of 3 nM[1].
Product Specifications
CAS Number
1888328-89-9
Product Name Alternative
GSK3536023
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/epz0025654.html
Smiles
O[C@H](CNC)COC1=CC=C(Cl)C(C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5=NC(N6CCC6)=NC=C5C4)=N2)=C1
Molecular Formula
C29H33ClN8O3
Molecular Weight
577.08
References & Citations
[1]Li ASM, et al., Chemical probes for protein arginine methyltransferases. Methods. 2020 Mar 15;175:30-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT6
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