Tarenflurbil (Standard)

Tarenflurbil (Standard) is the analytical standard of Tarenflurbil. This product is intended for research and analytical applications. Tarenflurbil ((R) -Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R) -Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.

Product Specifications

CAS Number

[51543-40-9]

Product Name Alternative

(R) -Flurbiprofen (Standard) ; MPC7869 (Standard)

UNSPSC

12352005

Target

Autophagy; RAR/RXR; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/tarenflurbil-standard.html

Smiles

O=C(O)[C@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

Molecular Formula

C15H13FO2

Molecular Weight

244.26

References & Citations

[1]You X, et al. Retinoid X receptor-alpha mediates (R) -flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111 (1) :142-9.|[2]Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287 (39) :32640-50.|[3]Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6 (11) :1398-422.