AM580

AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.

Product Specifications

CAS Number

[102121-60-8]

Product Name Alternative

CD336; NSC608001; Ro 40-6055

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AM580.html

Purity

99.70

Solubility

DMSO : ≥ 45 mg/mL|H2O : < 0.1 mg/mL

Smiles

CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C

Molecular Formula

C22H25NO3

Molecular Weight

351.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87 (4) :1520-31.|[2]Lu Y, et al. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580. Oncogene. 2010 Jun 24;29 (25) :3665-76.|[3]Bosch A, et al. Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Breast Cancer Res. 2012 Aug 24;14 (4) :R121.