L-Homocysteine

L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia[1][2].

Product Specifications

CAS Number

[6027-13-0]

UNSPSC

12352211

Hazard Statement

H302

Target

Cathepsin; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l-homocysteine.html

Purity

98.40

Solubility

DMSO : < 1 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

N[C@@H](CCS)C(O)=O

Molecular Formula

C4H9NO2S

Molecular Weight

135.19

Precautions

H302

References & Citations

[1]Finkelstein JD, et al. Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32 (4) :385-9.|[2]Leng YP, et al. l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. Br J Pharmacol. 2018 Apr;175 (8) :1157-1172.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Cathepsin L; Human Endogenous Metabolite

Available Sizes

Curated Selection

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