CKK-E12
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo
Product Specifications
CAS Number
1432494-65-9
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ckk-e12.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O
Molecular Formula
C60H120N4O6
Molecular Weight
993.62
Precautions
H315, H319, H320
References & Citations
[1]Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111 (15) :5753]. Proc Natl Acad Sci U S A. 2014;111 (11) :3955-3960. |[2]Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17 (3) :1326-1335. |[3]Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17 (3) :310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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