CKK-E12

CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo

Product Specifications

CAS Number

[1432494-65-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ckk-e12.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O

Molecular Formula

C60H120N4O6

Molecular Weight

993.62

Precautions

H315, H319, H320

References & Citations

[1]Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111 (15) :5753]. Proc Natl Acad Sci U S A. 2014;111 (11) :3955-3960. |[2]Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17 (3) :1326-1335. |[3]Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17 (3) :310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7.