AL-34662

AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor) . AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM) . AL-34662 is an ocular hypotensive agent[1][2].

Product Specifications

CAS Number

[210580-75-9]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/al-34662.html

Purity

99.19

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C

Molecular Formula

C10H13N3O

Molecular Weight

191.23

References & Citations

[1]Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23 (1) :1-13.|[2]Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174 (19) :3370-3381.