AL-34662
AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor) . AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM) . AL-34662 is an ocular hypotensive agent[1][2].
Product Specifications
CAS Number
210580-75-9
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/al-34662.html
Purity
99.19
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C=C1)C=NN2C[C@@H](N)C
Molecular Formula
C10H13N3O
Molecular Weight
191.23
References & Citations
[1]Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23 (1) :1-13.|[2]Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174 (19) :3370-3381.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
Available Sizes
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