Fibronectin Adhesion-promoting Peptide

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells[1][2].

Product Specifications

CAS Number

[125720-21-0]

Product Name Alternative

Heparin Binding Peptide

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Heparin_Binding_Peptide.html

Purity

98.50

Solubility

H2O : 2 mg/mL (ultrasonic; warming)

Smiles

CC[C@H](C)[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H]1N(C([C@H]2N(C([C@H](CCC(N)=O)NC([C@H](CC3=CNC4=C3C=CC=C4)N)=O)=O)CCC2)=O)CCC1)=O)=O)=O)=O

Molecular Formula

C47H74N16O10

Molecular Weight

1023.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35 (3) :879-90.|[2]Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12 (12) :1648-59.|[3]Lei J, Murphy WL, et al. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. Bioconjug Chem. 2018 Apr 18;29 (4) :878-884.