5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist[1][2][3][4]. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice[3][4].

Product Specifications

CAS Number

[74885-09-9]

Product Name Alternative

5-CT

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-carboxamidotryptamine.html

Purity

98.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(NC=C2CCN)C=C1)N

Molecular Formula

C11H13N3O

Molecular Weight

203.24

Precautions

H315, H319, H320

References & Citations

[1]Saxena PR, et al. Characterization of 5-hydroxytryptamine receptors in the cranial vasculature. Cephalalgia. 1989;9 Suppl 9:15-22.|[2]Saxena PR, et al. From serotonin receptor classification to the antimigraine drug sumatriptan. Cephalalgia. 1992 Aug;12 (4) :187-96.|[3]Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44 (8) :1031-7.|[4]Hurley PT, et al. Functional coupling of a recombinant human 5-HT5A receptor to G-proteins in HEK-293 cells. Br J Pharmacol. 1998 Jul;124 (6) :1238-44.|[5]Connor HE, et al. 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br J Pharmacol. 1986 Feb;87 (2) :417-26.