Pyributicarb

Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR) .

Product Specifications

CAS Number

[88678-67-5]

Product Name Alternative

TSH-888

UNSPSC

12352005

Hazard Statement

H410

Target

Cytochrome P450; Pregnane X Receptor (PXR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Pyributicarb.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(OC1=CC=CC(C(C)(C)C)=C1)N(C2=NC(OC)=CC=C2)C

Molecular Formula

C18H22N2O2S

Molecular Weight

330.44

Precautions

H410

References & Citations

[1]Matsubara T, et al. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos. 2007 May;35 (5) :728-33.|[2]Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280 (3) :77-87.