ON 108600
ON 108600 is a inhibitor for CK2 (Casein Kinase2) /TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].
Product Specifications
CAS Number
1585246-23-6
UNSPSC
12352005
Target
Casein Kinase; DYRK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/on-108600.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=CC=C1Cl)=C1CS(=O)(C2=CC=C(S/C(C(N3)=O)=C\C4=CC([N+]([O-])=O)=C(C=C4)O)C3=C2)=O
Molecular Formula
C22H14Cl2N2O6S2
Molecular Weight
537.39
References & Citations
[1]Katsutoshi Sato, et al. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun. 2021 Aug 3;12 (1) :4671.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2; DYRK1; DYRK2
Available Sizes
Frequently Asked Questions
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