ON 108600

ON 108600 is a inhibitor for CK2 (Casein Kinase2) /TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].

Product Specifications

CAS Number

[1585246-23-6]

UNSPSC

12352005

Target

Casein Kinase; DYRK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/on-108600.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(C=CC=C1Cl)=C1CS(=O)(C2=CC=C(S/C(C(N3)=O)=C\C4=CC([N+]([O-])=O)=C(C=C4)O)C3=C2)=O

Molecular Formula

C22H14Cl2N2O6S2

Molecular Weight

537.39

References & Citations

[1]Katsutoshi Sato, et al. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun. 2021 Aug 3;12 (1) :4671.