SGX-523

SGX523 is a exquisitely selective and ATP-competitive MET inhibitor. SGX523 potently inhibits MET with an IC50 of 4 nM and is >1,000-fold selective versus other protein kinases. Antitumor activity[1].

Product Specifications

CAS Number

[1022150-57-7]

UNSPSC

12352005

Hazard Statement

H302

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SGX-523.html

Purity

99.23

Solubility

DMSO : 30 mg/mL (ultrasonic)

Smiles

CN1N=CC(C2=NN3C(SC4=CC5=C(N=CC=C5)C=C4)=NN=C3C=C2)=C1

Molecular Formula

C18H13N7S

Molecular Weight

359.41

Precautions

H302

References & Citations

[1]Buchanan SG, et al. SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther, 2009, 8 (12), 3181-3190.