CB1R antagonist 1
CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of > 10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1].
Product Specifications
CAS Number
334668-69-8
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cb1r-antagonist-1.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1CCCCC1)N2CCN(S(=O)(C3=CC(C(F)(F)F)=CC=C3)=O)CC2
Molecular Formula
C18H23F3N2O3S
Molecular Weight
404.45
References & Citations
[1]Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52 (8) :2550-8
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1
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