CB1R antagonist 1

CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of > 10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1].

Product Specifications

CAS Number

[334668-69-8]

UNSPSC

12352005

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cb1r-antagonist-1.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1CCCCC1)N2CCN(S(=O)(C3=CC(C(F)(F)F)=CC=C3)=O)CC2

Molecular Formula

C18H23F3N2O3S

Molecular Weight

404.45

References & Citations

[1]Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52 (8) :2550-8